Promotion of mesangial cell proliferation by monokines.
نویسندگان
چکیده
منابع مشابه
Synergistic Stimulation of Macrophage Proliferation by the Monokines Tumor
The effects of pure recombinant human tumor necrosis factor-alpha (TNF) on the CSF-1 -stimulated proliferation of well-defined populations of murine macrophages are examined. Primary bone marrow-derived macrophages (BMM) from endotoxin-resistant C3H/HeJ mice were characterized for homogeneity in comparison with a cloned. growth factor-dependent macrophage cell line (Si ) also derived from C3H/H...
متن کاملInhibition of human mesangial cell proliferation by calcium channel blockers.
Human mesangial cells in culture proliferate in response to platelet-derived growth factor (PDGF) and thrombin. Both of these agents also induce changes in cytosolic calcium that are dependent on both mobilization of intracellular calcium and influx of extracellular calcium. We hypothesized that calcium channel blockers, by preventing influx of extracellular calcium, may inhibit proliferation i...
متن کاملThe regulation of mesangial cell proliferation.
Mesangial cell (MC) proliferation is a key pathological feature in a number of common human renal diseases including IgA, systemic lupus erythematosus and diabetic nephropathies. Knowledge of the role of MCs in normal glomeruli and of their response to pathological stimuli is crucial to the understanding of these disease processes. The purpose of understanding disease is ultimately to develop t...
متن کاملThromboxane A2, prostaglandins, and mesangial cell proliferation.
Much work has recently focused upon the cellular involvement of the mesangium in glomerular inflammation and fibrosclerosis. A host of mediators of inflammation have been identified and their actions studied in mesangial cell cultures [1]. The recent identification of functional receptors for prostaglandins (PG) and thromboxane A2 (TxA2) in cultured glomerular mesangial cells [2, 3] has prompte...
متن کاملPlasma Gelsolin Promotes Proliferation of Mesangial Cell in IgA Nephropathy.
BACKGROUND/AIMS Plasma gelsolin (pGSN) is an actin-binding protein that plays a critical role in the pathogenesis of rheumatoid arthritis. However, whether pGSN is involved in other immunological diseases remains unknown. This study focused on the relationship between pGSN and immunoglobulin A (IgA) nephropathy (IgAN). METHODS Two hundred patients with IgAN, 200 patients each with several oth...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Ensho
سال: 1990
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.10.103